MAGTON-D

Domperidone + Magaldrate + Simethicone Suspension.

Domperidone

About Domperidone

Antidopaminergic, Motility stimulant,Piperidine derivative, Antiemetic, anti-vertigo.

Mechanism of Action of Domperidone

Domperidone is a potent dopamine receptor antagonist. It acts centrally and blocks the Dopamine receptor in the Chemoreceptor trigger zone and produces Antiemetic effect. Domperidone acts peripherally in the gastrointestinal system and increases oesophageal peristalsis, oesophageal sphincter pressure and gastric motility. These all facilitates gastric emptying. Domperidone is used in migraine to relieve nausea and vomiting. Anaesthetic adjuncts: It is used preoperatively in order to reduce the post operative vomiting.

Pharmacokinets of Domperidone

Absorption: Domperidone is rapidly absorbed after oral administration. Since it undergoes first pass metabolism oral bioavailability is only 15 %. Distribution: It is widely distributed in the body in protein bound form. Metabolism: Domperidone undergoes metabolism in the liver. Excretion: It is excreted mainly in the faeces and also in the urine.

Onset of Action for Domperidone

30 - 60 minutes

Duration of Action for Domperidone

6 - 8 hours

Half Life of Domperidone

7.5 hours

Side Effects of Domperidone

1.Diarrhoea 2.Dry mouth 3.Galactorrhoea 4.Gynaecomastia 5.Skin rash 6.Abdominal discomfort 7.Dystonic reactions

Magaldrate

About Magaldrate

Chemical complex of aluminum and magnesium hydroxides, Antacid.

Mechanism of Action of Magaldrate

This neutralizes the gastric acid and increases the gastric pH. This reduces the direct acid irritant effect. It also enhances mucosal barrier integrity and improves gastroesophageal sphincter tone.

Pharmacokinets of Magaldrate

Absorption- Moderately absorbed after oral administration. Distribution- It is distributed through locally. Excretion- Excreted through feces and a small amount through breast milk.

Onset of Action for Magaldrate

20minutes

Duration of Action for Magaldrate

20 to 180 minutes

Half Life of Magaldrate

N/A

Side Effects of Magaldrate

1. Constipation 2. Diarrhea 3. Increased urine pH 4. Decreased serum potassium levels 5. Increased serum calcium levels

Simethicone

About Simethicone

Oral anti-foaming agent, Silicones, Antiflatulent.

Mechanism of Action of Simethicone

This anti-gas (anti-flatulence) medication acts in the stomach and intestines to change the surface tension of gas bubbles, enabling smaller bubbles to join together into bigger bubbles. It results elimination of gas more easily by belching or passing flatus.

Pharmacokinets of Simethicone

Excretion- Excreted through feces.

Onset of Action for Simethicone

N/A

Duration of Action for Simethicone

N/A

Half Life of Simethicone

N/A

Side Effects of Simethicone

1. Bloating 2. Constipation 3. Diarrhea 4. Gas 5. Heartburn